The plastic surgeons at Illume Cosmetic Surgery have incorporated EV treatment as part of their armamentarium of tools for the treatment of genetic hair loss.
EV’s are cell-derived vesicles that are present in many eukaryotic fluids, including blood, urine, and cultured medium of cell cultures. They are packaged inside cellular endosomes and secreted from the cell, and they are responsible for direct cell to cell communication.
Extracellular vesicles provide a natural and comprehensive activation of the body’s healing processes by systematically activating the complex array of cell signals required to restore and maintain tissue health.
As the technology and discovery of new methods of treating patients has evolved, scientific evidence shows that the optimal way to provide true regenerative therapy is to directly provide the signals as its own therapy and avoid potential issues with delivering and keeping transplanted cells alive.
Although not specifically FDA approved for hair loss, extracellular vesicles have shown promising clinical results for treating hair loss from physicians around the world.
*Individual results may vary.
Case Study – Male Pattern Baldness
Patient: 46 year old Male
- 2ml of xoGlo extracellular vesicles, diluted to 10ml with saline
- Treatment given approximately 0.5cm apart
- Results shown are at 2 weeks post procedure
At 2 weeks, patient has already shown new hair growth.*
Male Pattern Baldness
Patient: 43 year old male with receding frontal hair line as well as thinning of the crown area typical of male pattern baldness
- Applied 5cc xoGlo EV’s diluted 1:1 treatment 1cm apart evenly across the frontal hair line as well as the crown.
- Performed microneedling on patient’s head at a depth of 1.0 to create additional trauma in the treatment areas.
Noticeable results first observed 3 days out from initial treatment on the crown of thread where hair was still present but thin while noticeable results were observed at 2 weeks in the frontal area where hair was fully missing. Significant filling and coverage was observed on the crown area at 17 days from initial treatment.*
Female Androgenic Hair Loss
Patient: 31 year old female with long standing history of diffuse genetic hair loss (androgenetic alopecia).
- Single treatment with exosomes and micro needling
- 2ml xoGlo EV’s diluted with 8ml sterile saline
- Used 31 gauge needle with 10 1ml insulin syringe
- Treatment 0.1cc per treated site approximately 1cm apart
At one month, patient has already shown new hair growth.*
*Individual results may vary.
What are exosomes?
Exosomes are isolated from donated human amniotic mesenchymal stem cells and purified using proprietary processing. The unique benefit of these exosomes is that they are stem cell-derived and bring a wide array of growth factors. Because they’re so small and nimble, exosomes can remain hidden in the bloodstream, and carry multiple doses of proteins across barriers that cells are not able to cross.
What is exosome therapy for hair loss?
How long does it take to see results from exosome therapy for hair loss?
How long do I have to wait before another session of exosome therapy for hair loss?
How are the exosomes processed, and are they safe to use?
Extracellular vesicles are 30-150 nm in size and are involved in direct cell-to-cell communication.
- Provide over 1,000 regulatory proteins
- Involved in cell-to-cell communication
- Approximately 30-150nm in size (sterile filtered)
- Natural signals with no preservatives
Growth factors and EVs, including exosomes, are known to stimulate bioactivity and direct cellular communication.
The exosomes are isolated from living human bone marrow mesenchymal stem/stromal cells (MSCs) donors. The extracellular vesicles are purified using proprietary cGMP processing and are sterile filtered and tested per USP<71> sterility testing.
How many exosomes are in each vial?
How are exosome treatments different from PRP (Platelet Rich Plasma) treatments?
Before PRP was developed, stem cells would come from fat collected during liposuction. However, that process was painful and more expensive with the patient having to undergo two procedures. Again, the patient’s age and overall health came into play with the quantity and quality of the stem cells available.
We use exosomes which are sourced from amniotic mesenchymal stem cells. These exosomes are cryofrozen and packaged in a sterile vial ready for use.
How long do exosomes last in your body?
Can the patient take NSAIDS?
Are there any contraindications for exosome injections?
What preparation do I need for the day of the procedure?
- Drink a lot of fluid one day prior to the procedure
- Have breakfast the morning of their procedure
- Avoid Aspirin, Naproxen, Ibuprofen and other NSAIDs 3 days prior to the procedure and 3 weeks after the procedure.